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clustalw protein sequence alignments  (Accelrys)

 
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    Accelrys clustalw protein sequence alignments
    The amino acid sequences of known and predicted serotonin receptors were aligned using the <t>ClustalW</t> method and a Neighbor-Joining Best Tree was constructed from the alignment. The alignment included representative examples of all major classes of serotonergic GPCRs but only three clades are shown for simplicity. These include type 2 serotonin receptors (5HT2), type 7 (5HT7) and structurally related type 1 and type 5 receptors (5HT1/5). The outgroup in the alignment (not shown) was a distantly related rat metabotropic glutamate receptor (NP_058707). The tree was rooted to the outgroup and was tested by bootstrap analysis with 1000 iterations. The length of the branches is proportional to the genetic distance between sequences. Sequences were all obtained from the National Center for Biotechnology Information (NCBI). S. mansoni sequences are designated by their S. mansoni GeneDB “smp”designation number and are marked by arrows. Accession numbers for the remaining sequences are as follows: 5HT2_Drosophila (NP_730859); 5HT2_Lymnae (AAC16969.1), 5HT2(ser-1)_C. elegans (AAC15778); 5HT2B_Xenopus (NP_001082744); 5HT2A_human (NP_000612); 5HT2A_mouse (NP_766400); 5HT2B_human (NP_000858); 5HT2C_human (NP_000859); 5HT5B_mouse (NP_034613.2); 5HT5A_human (NP_076917.1); 5HT1_Helisoma (AAQ95277.1); 5HT1A_Xenopus (NP_001079299.1); 5HT1A_human (NP_000515.2); 5HT1A_chicken (NP_001163999.1); 5HT1D_dog (P11614); 5HT1A_pufferfish (O42385); 5HT1_Aplysia (NP_001191550); 5HT1(ser-4)_C. elegans (NP_497452); 5HT_Haemonchus (AAO45883); 5HT7_Xenopus (NP_001079253.1); 5HT7_human (NP_062873.1); 5HT7_chicken (NP_001167605.1) 5HT7_Helisoma (AAQ84306.1); 5HT7_Meleagris (XP_003206102); 5HT7_zebrafish (XP_690599); 5HT7_Clonorchis (GAA29051); 5HT7_Aedes (AF296125); 5HT7 (ser-7)_C. elegans (NP_741730); 5HT_Dugesia.1 (BAA22404); 5HT_Dugesia.4 (BAA22403); 5HT7_Dugesia (BAI44327.1); 5HT4_chicken (XP_414481.2); 5HT4_human (NP_000861.1); 5HT6_chicken (NP_001166911.1); 5HT6_human (NP_000862.1); 5HT6_mouse (NP_067333.1); ratmGlu.8393487; mGluR1_rat (NP_058707).
    Clustalw Protein Sequence Alignments, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    clustalw protein sequence alignments - by Bioz Stars, 2026-09
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    Images

    1) Product Images from "Serotonin Signaling in Schistosoma mansoni : A Serotonin–Activated G Protein-Coupled Receptor Controls Parasite Movement"

    Article Title: Serotonin Signaling in Schistosoma mansoni : A Serotonin–Activated G Protein-Coupled Receptor Controls Parasite Movement

    Journal: PLoS Pathogens

    doi: 10.1371/journal.ppat.1003878

    The amino acid sequences of known and predicted serotonin receptors were aligned using the ClustalW method and a Neighbor-Joining Best Tree was constructed from the alignment. The alignment included representative examples of all major classes of serotonergic GPCRs but only three clades are shown for simplicity. These include type 2 serotonin receptors (5HT2), type 7 (5HT7) and structurally related type 1 and type 5 receptors (5HT1/5). The outgroup in the alignment (not shown) was a distantly related rat metabotropic glutamate receptor (NP_058707). The tree was rooted to the outgroup and was tested by bootstrap analysis with 1000 iterations. The length of the branches is proportional to the genetic distance between sequences. Sequences were all obtained from the National Center for Biotechnology Information (NCBI). S. mansoni sequences are designated by their S. mansoni GeneDB “smp”designation number and are marked by arrows. Accession numbers for the remaining sequences are as follows: 5HT2_Drosophila (NP_730859); 5HT2_Lymnae (AAC16969.1), 5HT2(ser-1)_C. elegans (AAC15778); 5HT2B_Xenopus (NP_001082744); 5HT2A_human (NP_000612); 5HT2A_mouse (NP_766400); 5HT2B_human (NP_000858); 5HT2C_human (NP_000859); 5HT5B_mouse (NP_034613.2); 5HT5A_human (NP_076917.1); 5HT1_Helisoma (AAQ95277.1); 5HT1A_Xenopus (NP_001079299.1); 5HT1A_human (NP_000515.2); 5HT1A_chicken (NP_001163999.1); 5HT1D_dog (P11614); 5HT1A_pufferfish (O42385); 5HT1_Aplysia (NP_001191550); 5HT1(ser-4)_C. elegans (NP_497452); 5HT_Haemonchus (AAO45883); 5HT7_Xenopus (NP_001079253.1); 5HT7_human (NP_062873.1); 5HT7_chicken (NP_001167605.1) 5HT7_Helisoma (AAQ84306.1); 5HT7_Meleagris (XP_003206102); 5HT7_zebrafish (XP_690599); 5HT7_Clonorchis (GAA29051); 5HT7_Aedes (AF296125); 5HT7 (ser-7)_C. elegans (NP_741730); 5HT_Dugesia.1 (BAA22404); 5HT_Dugesia.4 (BAA22403); 5HT7_Dugesia (BAI44327.1); 5HT4_chicken (XP_414481.2); 5HT4_human (NP_000861.1); 5HT6_chicken (NP_001166911.1); 5HT6_human (NP_000862.1); 5HT6_mouse (NP_067333.1); ratmGlu.8393487; mGluR1_rat (NP_058707).
    Figure Legend Snippet: The amino acid sequences of known and predicted serotonin receptors were aligned using the ClustalW method and a Neighbor-Joining Best Tree was constructed from the alignment. The alignment included representative examples of all major classes of serotonergic GPCRs but only three clades are shown for simplicity. These include type 2 serotonin receptors (5HT2), type 7 (5HT7) and structurally related type 1 and type 5 receptors (5HT1/5). The outgroup in the alignment (not shown) was a distantly related rat metabotropic glutamate receptor (NP_058707). The tree was rooted to the outgroup and was tested by bootstrap analysis with 1000 iterations. The length of the branches is proportional to the genetic distance between sequences. Sequences were all obtained from the National Center for Biotechnology Information (NCBI). S. mansoni sequences are designated by their S. mansoni GeneDB “smp”designation number and are marked by arrows. Accession numbers for the remaining sequences are as follows: 5HT2_Drosophila (NP_730859); 5HT2_Lymnae (AAC16969.1), 5HT2(ser-1)_C. elegans (AAC15778); 5HT2B_Xenopus (NP_001082744); 5HT2A_human (NP_000612); 5HT2A_mouse (NP_766400); 5HT2B_human (NP_000858); 5HT2C_human (NP_000859); 5HT5B_mouse (NP_034613.2); 5HT5A_human (NP_076917.1); 5HT1_Helisoma (AAQ95277.1); 5HT1A_Xenopus (NP_001079299.1); 5HT1A_human (NP_000515.2); 5HT1A_chicken (NP_001163999.1); 5HT1D_dog (P11614); 5HT1A_pufferfish (O42385); 5HT1_Aplysia (NP_001191550); 5HT1(ser-4)_C. elegans (NP_497452); 5HT_Haemonchus (AAO45883); 5HT7_Xenopus (NP_001079253.1); 5HT7_human (NP_062873.1); 5HT7_chicken (NP_001167605.1) 5HT7_Helisoma (AAQ84306.1); 5HT7_Meleagris (XP_003206102); 5HT7_zebrafish (XP_690599); 5HT7_Clonorchis (GAA29051); 5HT7_Aedes (AF296125); 5HT7 (ser-7)_C. elegans (NP_741730); 5HT_Dugesia.1 (BAA22404); 5HT_Dugesia.4 (BAA22403); 5HT7_Dugesia (BAI44327.1); 5HT4_chicken (XP_414481.2); 5HT4_human (NP_000861.1); 5HT6_chicken (NP_001166911.1); 5HT6_human (NP_000862.1); 5HT6_mouse (NP_067333.1); ratmGlu.8393487; mGluR1_rat (NP_058707).

    Techniques Used: Construct

    Related Articles

    Sequencing:

    Article Title: Serotonin Signaling in Schistosoma mansoni : A Serotonin–Activated G Protein-Coupled Receptor Controls Parasite Movement
    Article Snippet: Statistical analyses of receptor activity were done using the Prism software package for Macintosh (v3.0a, Graphpad Software, San Diego, CA, USA). .. ClustalW protein sequence alignments and the construction of a phylogenetic tree were performed using MacVector 7.1.1 (Accelrys, Inc). .. Trees were built according to Neighbour-Joining method using the Best Tree mode available in MacVector and were verified by bootstrap analysis with 1000 replicates.



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    The amino acid sequences of known and predicted serotonin receptors were aligned using the ClustalW method and a Neighbor-Joining Best Tree was constructed from the alignment. The alignment included representative examples of all major classes of serotonergic GPCRs but only three clades are shown for simplicity. These include type 2 serotonin receptors (5HT2), type 7 (5HT7) and structurally related type 1 and type 5 receptors (5HT1/5). The outgroup in the alignment (not shown) was a distantly related rat metabotropic glutamate receptor (NP_058707). The tree was rooted to the outgroup and was tested by bootstrap analysis with 1000 iterations. The length of the branches is proportional to the genetic distance between sequences. Sequences were all obtained from the National Center for Biotechnology Information (NCBI). S. mansoni sequences are designated by their S. mansoni GeneDB “smp”designation number and are marked by arrows. Accession numbers for the remaining sequences are as follows: 5HT2_Drosophila (NP_730859); 5HT2_Lymnae (AAC16969.1), 5HT2(ser-1)_C. elegans (AAC15778); 5HT2B_Xenopus (NP_001082744); 5HT2A_human (NP_000612); 5HT2A_mouse (NP_766400); 5HT2B_human (NP_000858); 5HT2C_human (NP_000859); 5HT5B_mouse (NP_034613.2); 5HT5A_human (NP_076917.1); 5HT1_Helisoma (AAQ95277.1); 5HT1A_Xenopus (NP_001079299.1); 5HT1A_human (NP_000515.2); 5HT1A_chicken (NP_001163999.1); 5HT1D_dog (P11614); 5HT1A_pufferfish (O42385); 5HT1_Aplysia (NP_001191550); 5HT1(ser-4)_C. elegans (NP_497452); 5HT_Haemonchus (AAO45883); 5HT7_Xenopus (NP_001079253.1); 5HT7_human (NP_062873.1); 5HT7_chicken (NP_001167605.1) 5HT7_Helisoma (AAQ84306.1); 5HT7_Meleagris (XP_003206102); 5HT7_zebrafish (XP_690599); 5HT7_Clonorchis (GAA29051); 5HT7_Aedes (AF296125); 5HT7 (ser-7)_C. elegans (NP_741730); 5HT_Dugesia.1 (BAA22404); 5HT_Dugesia.4 (BAA22403); 5HT7_Dugesia (BAI44327.1); 5HT4_chicken (XP_414481.2); 5HT4_human (NP_000861.1); 5HT6_chicken (NP_001166911.1); 5HT6_human (NP_000862.1); 5HT6_mouse (NP_067333.1); ratmGlu.8393487; mGluR1_rat (NP_058707).

    Journal: PLoS Pathogens

    Article Title: Serotonin Signaling in Schistosoma mansoni : A Serotonin–Activated G Protein-Coupled Receptor Controls Parasite Movement

    doi: 10.1371/journal.ppat.1003878

    Figure Lengend Snippet: The amino acid sequences of known and predicted serotonin receptors were aligned using the ClustalW method and a Neighbor-Joining Best Tree was constructed from the alignment. The alignment included representative examples of all major classes of serotonergic GPCRs but only three clades are shown for simplicity. These include type 2 serotonin receptors (5HT2), type 7 (5HT7) and structurally related type 1 and type 5 receptors (5HT1/5). The outgroup in the alignment (not shown) was a distantly related rat metabotropic glutamate receptor (NP_058707). The tree was rooted to the outgroup and was tested by bootstrap analysis with 1000 iterations. The length of the branches is proportional to the genetic distance between sequences. Sequences were all obtained from the National Center for Biotechnology Information (NCBI). S. mansoni sequences are designated by their S. mansoni GeneDB “smp”designation number and are marked by arrows. Accession numbers for the remaining sequences are as follows: 5HT2_Drosophila (NP_730859); 5HT2_Lymnae (AAC16969.1), 5HT2(ser-1)_C. elegans (AAC15778); 5HT2B_Xenopus (NP_001082744); 5HT2A_human (NP_000612); 5HT2A_mouse (NP_766400); 5HT2B_human (NP_000858); 5HT2C_human (NP_000859); 5HT5B_mouse (NP_034613.2); 5HT5A_human (NP_076917.1); 5HT1_Helisoma (AAQ95277.1); 5HT1A_Xenopus (NP_001079299.1); 5HT1A_human (NP_000515.2); 5HT1A_chicken (NP_001163999.1); 5HT1D_dog (P11614); 5HT1A_pufferfish (O42385); 5HT1_Aplysia (NP_001191550); 5HT1(ser-4)_C. elegans (NP_497452); 5HT_Haemonchus (AAO45883); 5HT7_Xenopus (NP_001079253.1); 5HT7_human (NP_062873.1); 5HT7_chicken (NP_001167605.1) 5HT7_Helisoma (AAQ84306.1); 5HT7_Meleagris (XP_003206102); 5HT7_zebrafish (XP_690599); 5HT7_Clonorchis (GAA29051); 5HT7_Aedes (AF296125); 5HT7 (ser-7)_C. elegans (NP_741730); 5HT_Dugesia.1 (BAA22404); 5HT_Dugesia.4 (BAA22403); 5HT7_Dugesia (BAI44327.1); 5HT4_chicken (XP_414481.2); 5HT4_human (NP_000861.1); 5HT6_chicken (NP_001166911.1); 5HT6_human (NP_000862.1); 5HT6_mouse (NP_067333.1); ratmGlu.8393487; mGluR1_rat (NP_058707).

    Article Snippet: ClustalW protein sequence alignments and the construction of a phylogenetic tree were performed using MacVector 7.1.1 (Accelrys, Inc).

    Techniques: Construct